HEALS: Health and Environment-wide Associations based on Large population Surveys THE LARGEST RESEARCH PROJECT IN EUROPE ON ENVIRONMENT AND HEALTH

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HEALS: Health and Environment-wide Associations based on Large population Surveys THE LARGEST RESEARCH PROJECT IN EUROPE ON ENVIRONMENT AND HEALTH

WP17. WP17. Health and Exposure Assessment Survey (Exposure and Health Examination Survey – EXHES). The WP involves several countries of the European community.

An agreement was stipulated for the Center of Palermo with the Buccheri La Ferla hospital birth point.

 

www.heals-eu.eu

HEALS is a complete applied methodology which focuses on the different aspects of the individual assessment of exposure to conventional and emerging environmental stressors and on the prediction of associated health outcomes. Key health endpoints considered include: allergic respiratory disease, bronchial asthma, neurodevelopmental and neurodegenerative diseases, obesity and childhood type II diabetes. In the context of the project HEALS, the European Exposure and Health Examination Survey EXHES) aims to enroll and follow sets of mothers and children, singles and twins over time, in order to have data to construct the internal and external exposome and relate it to asthma, allergy, being overweight, obesity and neurodegenerative diseases.
EXHES is a longitudinal study in which 6,000 children, 1,500 of them twins, 5250 mothers, 5250 fathers, are expected to have participated at the end of the 1-year follow-up period.

During pregnancy::

  • recruitment and consent of the mother and father;
  • first self-administered questionnaires (risk factors and risk / health factors, pregnancy) delivered to the mother and father;
  • collection of urine, blood, saliva and hair samples from the mother (in consideration of the biological marker and homologic evaluations);
  • collection of urine, saliva and hair samples from the father (in view of a biological marker and homologic evaluations).

Upon delivery::

  • umbilical cord blood collection, pieces of cord tissue, pieces of placenta and baby hair, baby’s saliva, mother’s saliva (for biological and toxicological assessments). Furthermore, total IgE will be evaluated in umbilical cord blood as a marker of allergy predisposition and the results sent to parents with information on how to avoid allergies if the test is positive.

Post-Partum:

  • self-managed questionnaires with interviews (health and potential risk factors / risk factors) for mother and father;
  • collection of colostrum or breast milk and meconium (the latter for immune and microbiotic assessments).

Child Follow-up:

  • 1st year: questionnaires sent to family members at 4, 8 and 12 months (health and potential risk factors).

Funded by :     
Coordinated by:                
In collaboration with:     

 

Partners:

CNR STAFF

Stefania La Grutta  Research Director

Laura Montalbano  Post Doc Research fellow