Long-term impact of gestational and early-life dietary habits on infant gut immunity and disease risk. (EarlyFOOD)

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Long-term impact of gestational and early-life dietary habits on infant gut immunity and disease risk. (EarlyFOOD)

Objective

The EarlyFOOD project aims to assess the long-term effects of the exposure to antibodies, metabolites and toxins found in breast milk and dietary products on early-life gut colonization and immunity, and, in turn, on the risk of obesity, allergy and neuro-developmental diseases in children. The influence of environmental factors will also be assessed.

Methodologies


– Gather pre-existing (EDEN and HEALS) birth cohorts data (mother-child couples) and biospecimens (meconium, serum, maternal breast
milk);
– Measuring dietary derived toxins (dioxins, pesticides, bisphenol);
– Assessing exposure to other stressors (environmental pollutants, allergens);
– Assessing the impact of metabolites and toxins on gut microbiota and host immunity;
– Environment-wide association studies to identify dietary impact on human health.

Partners

  • CIMI (France)
  • SU (France)
  • TNO (The Netherland)
  • URV (Spain)
  • CNR IRIB-IFC (Italy)

 

Expected impact of the results

Identification of high-risk dietary profiles and environmental factors, such as pollutants and life style, may impact on food safety and quality. This may guide future health care campaigns in Europe and beyond, in the perspective of preventing metabolic and allergic diseases as well as neurobehavioral pathologies. This may benefit individual health and quality of life, but also the socio-economics of public health care systems.

 


IRIB STAFF

  • Stefania La Grutta Research Director
  • Velia Malizia Researcher
  • Giovanna Cilluffo Researcher
  • Laura Montalbano Researcher fellow
  • Salvatore Fasola Researcher fellow

 

Funded by :

 

Coordinators:   

 

With: