Seminar: Dr.  Fabrizio Chiodo 05 May 2021

Seminar: Dr. Fabrizio Chiodo 05 May 2021

Dr. Fabrizio Chiodo

Dr. Fabrizio Chiodo

Research Assistant Professor at the Italian National Research Council (CNR), Senior Researcher at Amsterdam Infection and Immunity Institute, Invited Lecturer at Havana University

Seminary: “Carbohydrate-Mediated “Innate” Considerations in Designing Vaccine-Candidates”.

05/05/2021 TEAMS at 02.00 p.m.


Carbohydrates play key immunological roles at the host-pathogens interface, and these interactions are extremely important while designing vaccine-candidates against infectious diseases. The traditional mechanism of action of conjugate-vaccines considers the peptides generated from the immunogenic carrier proteins (toxoids etc) to be responsible of T-cells activation, B-cells maturation and antibodies production.
However, in conjugate-vaccines, the carbohydrates could play a two-faced role: they are the antigens able to elicit specific anti-carbohydrate immune responses, and at the same time they could work as an immune- potentiator to enhance the immune responses to themselves. We demonstrated the active involvement of some S. pneumoniae polysaccharides in determining a series of in vitro innate immune responses in human.
Peripheral blood mononuclear cells were stimulated with approved and in clinical use S. pneumoniae carbohydrate-based vaccine coupled to the carrier tetanus toxoid and different read-out have been measured.
In addition, we also recently applied a rational “glyco-approach” to design different SARS-CoV-2 vaccine- candidates now in clinical trial.
In conclusion, our results aim at considering carbohydrate-mediated “innate” interactions while designing vaccine-candidates against infectious diseases.