Seminario: “Molecular snapshots of cell cycle control by cryo-EM”.

07/09/2021 alle 14.00 su TEAMS

Abstract:

The cell cycle is the fundamental biological process where the cell coordinates chromosome replication and segregation with cell growth and division. Progression through the cell cycle is orchestrated by a complex interplay of cell cycle regulators such as the cyclins, which are finely regulated at the level of gene expression, protein synthesis, degradation and phosphorylation. The cyclins activate the cyclin-dependent kinases, which promote cell cycle progression.
In our team we investigate key protein complex nanomachines regulating the cyclin protein levels by combining biochemical reconstitution methods and structural analysis by cryo-electron microscopy (cryo-EM), thereby providing molecular snapshots of cell cycle regulation events.

INFO : seminari.irib@irib.cnr.it