Dott. Luigi Mari

Post Doctoral Research Associate
St. Jude Children’s Research Hospital
Memphis, TN, United States

 

Understanding Parkin-mediated Cell Death

13/10/2022 – ore 15:00

Abstract: 

Parkin is an E3-ubiquitin ligase with a central role in mitochondrial quality control. Following translocation to the mitochondrial surface, it ubiquitylates several outer mitochondrial membrane proteins, which in turn recruit other proteins to initiate autophagy of damaged mitochondria (mitophagy) and maintain, in this way, cellular homeostasis. Because mutations in Parkin have been associated with genetic forms of early-onset Parkinson Diseases (PD), it has been proposed that a dysregulated mitophagy can cause PD due to the accumulation of defective mitochondria and subsequent loss of neuronal function, thus leading to cell death. However, how Parkin is involved in the regulation of cell death remains to be elucidated.

INFO : seminari.irib@irib.cnr.it