Dr. Valentina Di Biase obtained a degree in Pharmacy from the University G. d’Annunzio of Chieti–Pescara and a Ph.D. in Medical Sciences from the Medical University of Innsbruck (Austria). Her scientific training includes extensive pre- and postdoctoral research experience in international academic institutions as the University of Pennsylvania in Philadelphia (USA) and the Medical University of Innsbruck as well as several research stays to the Leibniz Institute for Neurobiology (Germany) and the Functional Genomics Institute of Montpellier (France). As Principal Investigator at the Medical University of Graz and the Medical University of Innsbruck, she led research projects on neuronal L-type calcium channels funded by the Austrian Science Fund (FWF). In this context, she coordinated research activities and supervised Ph.D. students, postdoctoral researchers, and master’s students. From 2023 to 2025, she served as a Seconded National Expert at the European Medicines Agency (EMA) in Amsterdam (The Netherlands), contributing to structured knowledge-exchange programmes between European research institutions and regulatory bodies. She joined the IRIB-CNR in Palermo in January 2026.

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My scientific interest focuses on ion channels in neurons and excitable tissues as cardiac and skeletal muscle cells. My research addresses the role of calcium channel trafficking and regulation in neuronal function, differentiation, and development. Disruption of these mechanisms is a central driver of neurological and psychiatric disorders with unmet clinical needs. By dissecting calcium channel pathophysiology, my work aims to enable the development of next-generation therapeutic strategies.

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I graduated magna cum laude from the University of Rome Tor Vergata with a Master’s degree in Molecular Biology. I obtained my Ph.D. in Biomedical Sciences from the Catholic University of Leuven, Belgium, where I discovered a new role for the Fragile X Mental Retardation Protein in breast cancer progression.
My scientific work has been published in several high-quality peer-reviewed journals, and part of my research is protected by a registered patent. I also work as a project manager and scientific writer for Horizon Europe SME Instrument, and I serve as a reviewer for multiple peer-review journals.
I joined the National Research Council (CNR) in 2019, where I am currently a Senior Researcher and Head of the JOI-A (Joint Lab for Organ-on-Chip and Integrated AI) Lab.

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My research focuses on uncovering the mechanisms that drive human diseases such as cancer and neurodevelopmental disorders, and on translating these insights into advanced preclinical models for personalized therapy.
My work is rooted in the development of integrated platforms from the Digital Twin to the Organ-on-Chip, where microengineering meets human health to create systems that better capture patient-specific disease biology.
Within this framework, I design and develop organ-on-chip platforms—microphysiological systems that reproduce key features of human tissues. These models offer powerful tools to study tumour behaviour and to test personalized therapeutic strategies with greater accuracy and translational relevance. By combining computational modelling, digital-twin methodologies and microfluidic engineering, my research aims to bridge the gap between in vitro experiments and clinical applications.

This research is conducted in the JOI-A Lab, which I head—a joint laboratory established between the Department of Biomedical Sciences (DSB) and the Charles Darwin Department of Biology and Biotechnology at Sapienza University.

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Awarded for her scientific contributions at Rome’s Campidoglio during the RomaRose event, winner of the Bianca di Navarra Prize, and recipient of other scientific awards in both Belgium and Italy.